Product Overview & China Production Capacity
Decarboxy Carnosine HCl (CAS 57022-38-5, also known as Carcinine hydrochloride) is a decarboxylated derivative of carnosine (β-alanyl-histamine) used in cosmetic and biotech formulations as an anti-glycation, anti-aging, and skin-brightening active ingredient. Chinese peptide and fine chemical manufacturers produce Decarboxy Carnosine HCl through chemical synthesis using β-alanine and histamine coupling or enzymatic decarboxylation routes, with several specialized facilities in Jiangsu, Zhejiang, and Shanghai achieving annual capacities of hundreds of metric tons.
In cosmetic applications, Decarboxy Carnosine HCl inhibits advanced glycation end-product (AGE) formation, protecting skin proteins (collagen, elastin) from glucose-mediated cross-linking that leads to wrinkles and loss of elasticity. It also exhibits antioxidant properties and melanogenesis modulation activity. Chinese manufacturers offer multiple purity grades from 95% to ≥99% for cosmetic formulation, research, and biotech applications, produced under controlled pharmaceutical conditions with full analytical documentation.
Manufacturing Standards & Quality Assurance
Production facilities hold ISO 9001:2015, ISO 22716, and pharmaceutical quality certifications. Quality testing includes assay (HPLC), identity confirmation (MS, NMR), specific rotation, residual solvents, related substances, water content, heavy metals, and microbial limits. Products are manufactured under controlled conditions with validated analytical methods and comprehensive batch documentation.
Synthesis involves peptide coupling chemistry with protecting group strategies or direct condensation under optimized reaction conditions. Multi-step purification including recrystallization and preparative chromatography achieves target purity. Each batch undergoes full structural characterization and purity verification before release. Stability data is generated under ICH conditions to support shelf-life specifications.
Technical Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 57022-38-5 |
| Chemical Name | Decarboxy Carnosine HCl (Carcinine HCl) |
| Molecular Formula | C₈H₁₄N₃O·HCl |
| Appearance | White to off-white powder |
| Assay (HPLC) | ≥98.0% |
| Related Substances | ≤1.0% total |
| Water Content | ≤2.0% |
| Residual Solvents | Meets ICH Q3C |
| Heavy Metals (Pb) | ≤10 ppm |
| Application | Cosmetic, biotech, research |
Packaging & Export Logistics
Decarboxy Carnosine HCl is supplied in 100 g, 500 g, 1 kg, or 5 kg aluminum foil bags within fiber drums, stored under cool, dry conditions protected from light. Lead time is 10–15 business days. FOB from Shanghai or Nanjing; CIF and DDP terms available.
Documentation includes CoA, SDS, HPLC chromatograms, MS/NMR spectral data, and stability reports. Small MOQs are available for formulation development and pilot-scale production.
China Supply Advantage
China’s advanced peptide chemistry capabilities and competitive manufacturing costs deliver Decarboxy Carnosine HCl at 30–50% below European specialty chemical pricing. Multiple experienced fine chemical and peptide manufacturers ensure supply alternatives and competitive quotations. Chinese producers serve cosmetic active ingredient companies worldwide with consistent purity and responsive technical support for custom synthesis and formulation development projects.