Suzhou Pharmaceutical Technology Co., Ltd. (China) supplies Daptomycin CAS 103060-53-3 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Daptomycin |
|---|---|
| Structural Formula |  |
| CAS Number | 103060-53-3 |
| Alias / Common Name | Cidecin; Cubicin; LY-146032; Daptomycinum; Daptomycine; β-Daptomycin |
| Molecular Formula | C72H101N17O26 |
| Molecular Weight | 1620.7 g/mol |
| InChIKey | DOAKLVKFURWEDJ-QCMAZARJSA-N |
| Purity / Grade | ≥93.0% potency (HPLC); confirm by batch COA |
| Appearance | Light yellow to yellow lyophilized powder |
| Pharmacopoeial Standard | USP / EP 11.0 |
| Storage | 2–8°C, protect from light; shelf life per batch COA |
| MOQ | 100 g (evaluation); 1 kg (commercial) |
Daptomycin (CAS 103060-53-3) is supplied by Suzhou Pharmaceutical Technology Co., Ltd. for B2B pharmaceutical procurement programs requiring fermentation-derived lipopeptide antibiotics with documented analytical quality. A cyclic lipopeptide produced by Streptomyces roseosporus fermentation, daptomycin is active against gram-positive pathogens including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE). Supply documentation includes COA (potency, impurities, endotoxin, moisture), MSDS and certificate of origin for export to South America, Europe, Australia, New Zealand, Mexico and Canada.
> Applications
Gram-Positive Infections Including MRSA and VRE
Daptomycin is indicated for bacteremia and right-sided endocarditis caused by S. aureus, and for skin and soft-tissue infections (ABSSSI) caused by susceptible gram-positive organisms. In a randomised controlled trial (Fowler VG et al., N Engl J Med, 2006;355(7):653–665, doi:10.1056/NEJMoa053783, n=246), daptomycin demonstrated non-inferior clinical success rates against standard-of-care therapy for S. aureus bacteremia and right-sided endocarditis, establishing daptomycin as a primary reference API in this category. Procurement teams review daptomycin for MRSA programs, complex skin infections and specialty antimicrobial formulation pipelines.
Specialty API for Antimicrobial Formulation Programs
Daptomycin is evaluated as a reference API for injectable antimicrobial products requiring USP or EP pharmacopoeial compliance. Key analytical quality attributes reviewed during qualification include HPLC potency (per USP <621>), anhydro-daptomycin content (key degradation impurity, USP limit ≤2.0%), bacterial endotoxin (≤0.5 EU/mg for injectable grade), residual solvents (ICH Q3C), and water content (Karl Fischer). Stability studies follow ICH Q1A guidelines; 24-month shelf life data at 2–8°C is available for commercial batches.
B2B Sourcing and Supply Chain Development
Daptomycin procurement programs are typically structured in three stages: analytical evaluation using reference standard comparison; qualification lot (100 g–1 kg) with extended characterisation; and commercial supply commitment. Suzhou Pharmaceutical Technology Co., Ltd. supports all three stages with consistent documentation packages and analytical method transfer support where required.
> Sourcing & Supply
Suzhou Pharmaceutical Technology Co., Ltd. supplies daptomycin to B2B buyers in South America, Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada. Primary export destinations in South America include Argentina, Colombia, Chile, Peru, Ecuador, Uruguay, Bolivia, Brazil, Paraguay and Venezuela.
- Evaluation quantities (100 g–1 kg): shipped with COA, MSDS, analytical method summary and batch documentation.
- Commercial lots (5 kg+): supply is confirmed against buyer specification, packaging format (amber glass, nitrogen atmosphere), cold-chain logistics plan and import documentation requirements.
- Lead time: ex-stock quantities available for rapid evaluation; made-to-order batches require advance planning. Contact for current stock status.
> Quality & Documentation
Standard documentation with each daptomycin shipment: Certificate of Analysis (potency, anhydro-daptomycin, related substances by HPLC, bacterial endotoxin, water, appearance, residual solvents); MSDS/SDS (GHS format); Certificate of Origin. For regulated-market qualification programs, additional documents including batch production records, analytical method validation summaries and stability data can be discussed on a project basis. COA and MSDS are provided in English; Spanish-language documentation available for South American import programs.
> Packaging
Daptomycin API is packaged as lyophilised powder in pharmaceutical-grade amber glass bottles sealed under nitrogen atmosphere. Standard export pack sizes: 5 g, 10 g, 50 g, 100 g, 500 g, 1 kg per unit. Outer packaging: corrugated carton with desiccant and temperature indicator card. Cold-chain shipping (2–8°C) with validated insulated packaging; continuous temperature data logger included with each shipment. Custom packaging formats are reviewed for commercial lots. Labels in English and Spanish for South American destinations.
> Pricing & MOQ
MOQ: 100 g for analytical evaluation and qualification. Commercial lots from 1 kg. Pricing is quoted by specification (USP/EP grade), analytical scope, packaging format, quantity and destination. Payment: 100% T/T before dispatch unless otherwise agreed. Spot availability and pricing quotations are provided within 2 business days of inquiry with clear specification details.
> Regulatory & Compounding Context
Daptomycin supplied by Suzhou Pharmaceutical Technology Co., Ltd. is intended for B2B pharmaceutical development, qualification and commercial procurement. Finished-product registration, market authorisation, labelling and distribution are the responsibility of the buying organisation. Buyers importing into South American markets (ANMAT, INVIMA, DIGEMID, ISP) should confirm API import requirements and dossier documentation needs with local regulatory counsel before placing commercial orders.
> Alias Index
- Primary name: Daptomycin
- CAS Number: 103060-53-3
- Molecular formula: C72H101N17O26 (MW 1620.7 g/mol)
- InChIKey: DOAKLVKFURWEDJ-QCMAZARJSA-N
- Trade names / aliases: Cidecin; Cubicin; LY-146032; Daptomycinum (Latin); Daptomycine (French)
- Pharmacopoeial monograph: USP Daptomycin; EP 11.0 Daptomycin
- Search terms: Daptomycin supplier South America; Daptomycin API bulk; CAS 103060-53-3 buy; Daptomycin manufacturer China
> FAQ
What is the CAS number (103060-53-3) and molecular formula for daptomycin?
Daptomycin CAS number is 103060-53-3. Molecular formula: C72H101N17O26; molecular weight: 1620.7 g/mol; InChIKey: DOAKLVKFURWEDJ-QCMAZARJSA-N. The IUPAC name is a complex cyclic lipodepsipeptide structure. Pharmacopoeial synonyms: USP Daptomycin, EP Daptomycinum.
What pharmacopoeial standard does your daptomycin meet?
Daptomycin supplied by Suzhou Pharmaceutical Technology Co., Ltd. is tested to USP and EP 11.0 specifications. Key parameters: potency ≥93.0% (HPLC), anhydro-daptomycin ≤2.0%, bacterial endotoxin ≤0.5 EU/mg, water content ≤5.0%. Full COA with all pharmacopoeial test results is provided with each batch.
What documents are available with each daptomycin order?
Standard documents: COA (HPLC potency, impurity profile, endotoxin, water content, residual solvents, appearance); MSDS/SDS (GHS); Certificate of Origin. Stability data, analytical method summaries and batch production documentation available for formal qualification programs.
What is the minimum order quantity (MOQ) for daptomycin?
MOQ is 100 g for initial analytical evaluation and qualification. Commercial lots start from 1 kg. Smaller research quantities (5–50 g) can be reviewed on a case-by-case basis for established buyers. API projects often require a qualification phase before commercial volumes are confirmed.
How is daptomycin packaged and shipped?
Daptomycin is supplied as lyophilised powder in amber glass bottles under nitrogen. Cold-chain shipping (2–8°C) is mandatory. Validated insulated packaging with continuous temperature data logger accompanies every shipment. Air freight is standard for daptomycin due to its temperature sensitivity and high value. Shipping documents include commercial invoice, packing list, COO and air waybill.
Can Suzhou Pharmaceutical Technology supply daptomycin to Argentina, Colombia and Chile?
Yes. Daptomycin supply to Argentina (ANMAT), Colombia (INVIMA) and Chile (ISP) is supported. Documentation packages including COA, MSDS and COO aligned to South American import requirements are provided. API import regulatory requirements for each destination should be confirmed with local counsel.
Do you supply daptomycin to Brazil, Peru, Ecuador and other South American countries?
Yes. Suzhou Pharmaceutical Technology supplies daptomycin to B2B buyers across South America including Brazil, Peru, Ecuador, Uruguay, Bolivia, Paraguay and Venezuela. Sea freight and air freight options are available. Contact for current pricing and transit time estimates to your destination port.
Can UK and European pharmaceutical buyers source daptomycin from your company?
Yes. Daptomycin supply to the United Kingdom, Germany, France, Italy, Spain, Netherlands, Poland and other European markets is available. EU import documentation (ASMF reference, EU COO, customs HS code) is discussed on a project basis. Buyers in regulated EU markets should confirm API import and technical file requirements with their regulatory team.
Is daptomycin available for buyers in Australia, New Zealand, Mexico and Canada?
Yes. Suzhou Pharmaceutical Technology supplies daptomycin to buyers in Australia, New Zealand, Mexico and Canada. TGA, Cofepris and Health Canada import requirements and documentation expectations are discussed on a project basis.
What is the difference between daptomycin and vancomycin for gram-positive infections?
Daptomycin (CAS 103060-53-3) is a lipopeptide that disrupts the bacterial cell membrane in a calcium-dependent manner, bactericidal against non-dividing cells. Vancomycin (CAS 1404-93-9) is a glycopeptide that inhibits cell-wall synthesis. Daptomycin has demonstrated activity against some vancomycin-intermediate S. aureus (VISA) strains and is effective for right-sided endocarditis where vancomycin has limitations.
What is anhydro-daptomycin and why is it important?
Anhydro-daptomycin is the primary degradation product of daptomycin formed by dehydration at the threonine residue. It is controlled in the USP monograph at ≤2.0%. Elevated anhydro-daptomycin indicates degradation and reduced potency. COA data for anhydro-daptomycin is included as a standard test parameter with each batch from Suzhou Pharmaceutical Technology.
How should daptomycin be stored to maintain stability?
Store daptomycin at 2–8°C, protected from light and moisture. Do not freeze lyophilised powder unless validated for your specific formulation. Shelf life is confirmed per batch COA; typically 24 months from manufacture date when stored correctly. During in-use handling, protect from humidity and elevated temperatures.
Last reviewed: June 2026
Sample and research orders (≤10 kg) are dispatched with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package on request.