Product Overview & China Production Capacity
N-Carbamyl-L-Glutamic Acid (NCG, CAS 1188-38-1, molecular formula C₆H₁₀N₂O₅, MW 190.15) is a structural analog of N-acetylglutamate (NAG) that activates carbamoyl phosphate synthetase I (CPS I) in the urea cycle. NCG is used as a pharmaceutical active ingredient for the treatment of N-acetylglutamate synthase (NAGS) deficiency and as a nutritional supplement in animal husbandry to improve nitrogen utilization efficiency. China has emerged as a major global NCG producer with specialized manufacturing facilities in Shandong, Jiangsu, and Hubei provinces achieving annual capacities of several thousand metric tons.
In pharmaceutical applications, NCG (marketed as Carbaglu/carglumic acid) is an orphan drug for NAGS deficiency-related hyperammonemia. In animal nutrition, NCG supplementation improves arginine synthesis, enhances immune function, and promotes growth performance in swine and poultry. Chinese manufacturers produce NCG through chemical synthesis from L-glutamic acid and potassium cyanate, offering multiple purity grades from feed (≥97%) to pharmaceutical (≥99%) quality.
Manufacturing Standards & Quality Assurance
Production facilities hold ISO 9001:2015 and FAMI-QS certifications. Quality testing includes assay (HPLC), specific rotation, related substances, residual solvents, heavy metals, water content, residue on ignition, and microbial limits. Pharmaceutical-grade NCG is produced under controlled pharmaceutical conditions with validated analytical methods and complete impurity profiling. Feed-grade NCG meets regulatory requirements for animal feed additives.
Synthesis involves carbamylation of L-glutamic acid under controlled alkaline conditions. Purification through pH adjustment, crystallization, and recrystallization achieves target purity. Chiral purity is verified by specific rotation and chiral HPLC to confirm L-configuration. Full structural characterization (NMR, MS, IR) is performed on each production campaign.
Technical Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 1188-38-1 |
| Molecular Formula | C₆H₁₀N₂O₅ |
| Molecular Weight | 190.15 g/mol |
| Appearance | White crystalline powder |
| Assay (HPLC) | ≥99.0% (pharma) / ≥97.0% (feed) |
| Specific Rotation [α]D²⁰ | +14.0° to +18.0° |
| Related Substances | ≤0.5% total (pharma grade) |
| Water Content | ≤1.0% |
| Heavy Metals (Pb) | ≤10 ppm |
| Application | Pharma API, feed additive |
Packaging & Export Logistics
NCG is supplied in 1 kg, 5 kg, or 25 kg aluminum foil bags within fiber drums, stored under cool, dry conditions. Lead time is 10–15 business days. FOB from Shanghai, Qingdao, or Nanjing; CIF and DDP terms available.
Documentation includes CoA, SDS, DMF reference (pharma grade), and regulatory compliance certificates. Non-hazardous classification facilitates global shipping.
China Supply Advantage
China’s competitive L-glutamic acid production (from fermentation) provides cost-effective feedstock for NCG synthesis, delivering competitive pricing 30–50% below Western specialty pharmaceutical sources. Experienced fine chemical and pharma API manufacturers ensure consistent quality with the regulatory documentation required for global market access. Chinese NCG producers serve pharmaceutical companies, animal nutrition formulators, and research institutions worldwide.