Product Overview & China Production Capacity
N,N-Dimethylacetamide (DMAc, CAS 127-19-5, molecular formula C₄H₉NO, MW 87.12) is a highly polar aprotic solvent used extensively in pharmaceutical synthesis, polymer processing, and fiber spinning. Chinese production facilities generate over 200,000 metric tons annually through acetic acid and dimethylamine reaction routes, with key manufacturing clusters in Shandong, Jiangsu, and Zhejiang. China commands a dominant share of global DMAc output, enabling manufacturer-direct supply at highly competitive pricing for pharmaceutical and industrial buyers.
DMAc dissolves a remarkably broad spectrum of organic and inorganic compounds, making it invaluable as a reaction medium for API synthesis, a solvent for polyimide and polyamide processing, and a crystallization solvent in pharmaceutical purification steps. Its high boiling point (165 °C), thermal stability, and water miscibility provide formulation flexibility. Chinese manufacturers offer both technical and pharma-grade DMAc with purity levels reaching 99.9%, produced in dedicated distillation trains with automated quality monitoring.
Manufacturing Standards & Quality Assurance
Production sites maintain ISO 9001:2015 quality management systems, ISO 14001 environmental certifications, and compliance with REACH registration requirements for EU market access. Pharma-grade DMAc undergoes GC purity analysis, water content determination (Karl Fischer), acidity testing, color evaluation, and heavy metals screening. Residual dimethylamine and acetic acid levels are monitored to ensure compliance with ICH Q3C solvent residue guidelines.
Automated process controls govern reaction stoichiometry, distillation temperatures, and product collection parameters. Electronic batch records with full traceability are maintained for every production campaign. Annual third-party audits verify continued compliance with quality system standards.
Technical Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 127-19-5 |
| Molecular Formula | C₄H₉NO |
| Molecular Weight | 87.12 g/mol |
| Appearance | Colorless transparent liquid |
| Purity (GC) | ≥99.9% |
| Boiling Point | 165 °C |
| Density (20 °C) | 0.937–0.942 g/mL |
| Water Content | ≤0.05% |
| Color (APHA) | ≤10 |
| Acidity (as Acetic Acid) | ≤0.005% |
Packaging & Export Logistics
DMAc is available in 200 kg galvanized steel drums, 1,000 kg IBC totes, and ISO tank containers for bulk supply. All packaging meets IMDG Code and UN transport specifications. Drums are secured on wooden pallets with steel strapping for safe ocean freight. Standard production lead time is 7–10 business days, with shipments from Qingdao, Shanghai, or Nanjing ports.
Complete export documentation including CoA, SDS, dangerous goods declaration, and customs paperwork is provided. DDP delivery to major global destinations can be arranged with door-to-door tracking.
China Supply Advantage
Direct direct procurement of DMAc from China provides cost savings of 20–35% versus Western alternatives. Large-scale integrated production from basic chemical feedstocks ensures price stability even during global supply chain disruptions. Chinese DMAc suppliers serve the world’s largest polymer fiber and pharmaceutical manufacturers, demonstrating consistent quality and delivery performance. Multilingual commercial teams provide responsive quotation, sample, and technical support services tailored to international customer requirements.