Product Overview & China Production Capacity
Polyethylene Glycol 6000 (PEG 6000, CAS 25322-68-3, average MW ~6,000) is a high-molecular-weight solid PEG grade widely used as a tablet binder, film-coating plasticizer, suppository hardener, and solid dispersion carrier in pharmaceutical manufacturing. Chinese facilities produce pharma-grade PEG 6000 in large-scale ethylene oxide polymerization reactors with precise molecular weight targeting, contributing to China’s position as the global leader in PEG production with combined annual output exceeding 1.5 million metric tons across all grades.
PEG 6000 provides superior binding strength in tablet formulations and excellent film flexibility when used as a coating plasticizer. In hot-melt extrusion and spray-drying processes, it serves as a hydrophilic carrier for amorphous solid dispersions that enhance the bioavailability of poorly soluble APIs. Its higher melting point (58–63 °C) compared to lower MW PEGs makes it suitable for tropical-climate formulations where product stability at elevated temperatures is essential.
Manufacturing Standards & Quality Assurance
Production takes place under ISO 9001:2015, and kosher/halal certified conditions. Analytical testing covers hydroxyl value, molecular weight distribution (GPC), ethylene glycol and diethylene glycol content, residual ethylene oxide, heavy metals, color, pH, and microbiological parameters. All batches comply with USP/NF Macrogol 6000, EP, and ChP monograph standards. DMF and CEP filings are maintained for global market access.
Continuous process monitoring ensures reaction conditions remain within validated parameters. Product is cooled, flaked or prilled, and packaged in climate-controlled areas to prevent moisture uptake. Full batch genealogy from raw materials through finished product is recorded in validated electronic systems.
Technical Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 25322-68-3 |
| Average Molecular Weight | 5,500–6,500 |
| Appearance | White flakes or powder |
| Hydroxyl Value | 17–21 mg KOH/g |
| Melting Point | 58–63 °C |
| pH (5% aqueous) | 4.5–7.5 |
| Water Content | ≤1.0% |
| Ethylene Glycol + DEG | ≤0.25% |
| Heavy Metals | ≤10 ppm |
| Pharmacopoeial Compliance | USP/NF, EP, JP, ChP |
Packaging & Export Logistics
PEG 6000 is packed in 25 kg PE-lined kraft bags or 25 kg fiber drums on standard pallets. Bulk supply in FIBCs (500 kg or 1,000 kg) is available for high-volume orders. All packaging conforms to food-contact regulations. Lead time is 10–15 business days with shipment from Shanghai, Dalian, or Qingdao ports under FOB, CIF, or DDP terms.
Documentation includes CoA, SDS, packing list, commercial invoice, and regulatory support files. Samples are available for qualification testing prior to commercial order placement.
China Supply Advantage
Direct PEG 6000 from China delivers cost reductions of 25–40% compared to Western-sourced material, without compromising pharmacopoeial compliance or quality consistency. China’s vertically integrated petrochemical-to-excipient supply chains ensure stable production even during periods of global feedstock volatility. With decades of export experience and proven performance under multinational pharma company audit programs, Chinese PEG 6000 producers offer the reliability and documentation rigor required for global pharmaceutical supply chains.