Product Overview & China Production Capacity
Rutin (Rutoside, CAS 153-18-4, molecular formula C₂₇H₃₀O₁₆, MW 610.52) is a flavonoid glycoside (quercetin-3-O-rutinoside) extracted from Sophora japonica flower buds, buckwheat, and citrus peels, widely used as a vascular protectant, antioxidant, and anti-inflammatory agent in pharmaceutical and nutraceutical products. China is the world’s dominant rutin producer with annual output exceeding 8,000 metric tons from extraction facilities in Shandong, Anhui, Henan, and Shaanxi provinces processing abundant Sophora japonica bud resources.
Rutin strengthens capillary walls, reduces vascular permeability, and exhibits anti-platelet aggregation activity, making it a widely prescribed bioflavonoid for chronic venous insufficiency and capillary fragility conditions. It also serves as the primary feedstock for quercetin production through hydrolysis. Chinese manufacturers offer rutin in multiple grades from NF-grade (≥95%) to high-purity pharmaceutical (≥98%) quality, extracted using water or ethanol-based processes.
Manufacturing Standards & Quality Assurance
Production facilities hold ISO 9001:2015, ISO 22000, and kosher/halal certifications. Quality testing includes assay (HPLC/UV), identification (HPLC, UV spectrum), loss on drying, residue on ignition, heavy metals, pesticide residues, solvent residues, and microbial limits. Products comply with USP/NF, EP, JP, and ChP monograph specifications.
Extraction involves hot water or ethanol extraction of dried Sophora japonica buds, followed by concentration, pH adjustment for selective precipitation, filtration, and drying. Recrystallization from water-ethanol systems achieves pharma-grade purity. Each batch is verified by HPLC against certified reference standards with full impurity profiling.
Technical Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 153-18-4 |
| Molecular Formula | C₂₇H₃₀O₁₆ |
| Molecular Weight | 610.52 g/mol |
| Appearance | Yellow to yellowish-green crystalline powder |
| Assay (HPLC) | ≥95% (NF grade) / ≥98% (pharma) |
| Source | Sophora japonica bud extract |
| Loss on Drying | ≤6.0% |
| Residue on Ignition | ≤0.2% |
| Heavy Metals (Pb) | ≤5 ppm |
| Pharmacopoeial Compliance | USP/NF, EP, JP, ChP |
Packaging & Export Logistics
Rutin is packed in 5 kg, 10 kg, or 25 kg PE-lined fiber drums or aluminum foil bags, stored under cool, dry conditions protected from light. Lead time is 7–12 business days. FOB from Shanghai, Qingdao, or Xi’an; CIF and DDP terms available.
Light-protective packaging preserves product color and potency. Documentation includes CoA, SDS, kosher/halal certificates, and phytosanitary certificates.
China Supply Advantage
China’s vast Sophora japonica tree resources and established flavonoid extraction industry deliver rutin at 30–50% below alternative global sources. Decades of extraction experience and optimized processing technology ensure consistent pharmacopoeial-grade quality. Chinese rutin producers serve pharmaceutical companies, supplement manufacturers, and quercetin producers worldwide with the scale and reliability required for global supply chain integration.