Suzhou Pharmaceutical Technology Co., Ltd. (China) supplies Trilostane API CAS 13647-35-3 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Trilostane — Overview
Trilostane (CAS: 13647-35-3, also known as Win 24,540) is a synthetic steroidal 3β-hydroxysteroid dehydrogenase (3β-HSD) inhibitor used as a pharmaceutical API in veterinary medicine. It is the active ingredient in Vetoryl® (Dechra Pharmaceuticals), the only veterinary-licensed trilostane product approved for canine hyperadrenocorticism (Cushing’s disease). Suzhou Pharmaceutical Technology Co., Ltd. supplies ≥98% Trilostane in bulk from Suzhou, China, with export to global markets and documentation including COA and MSDS included.
| Product Name | Trilostane |
| Structural Formula |  |
| Alias | Win 24,540; Vetoryl (brand); Modrenal |
| CAS Number | 13647-35-3 |
| Molecular Formula | C₂₀H₂₇NO₃ |
| Molecular Weight | 329.44 g/mol |
| Purity | ≥98% (HPLC) |
| Appearance | White to off-white crystalline powder |
| Storage | 2–8°C, protected from light, dry conditions |
> Applications
Trilostane blocks 3β-HSD, the enzyme that converts pregnenolone to progesterone and other Δ5 steroids to their Δ4-3-keto counterparts in the adrenal cortex. By interrupting this step, trilostane reduces synthesis of cortisol, aldosterone, and androstenedione in a dose-dependent, reversible manner. Unlike mitotane, it does not destroy adrenocortical tissue, which gives it a more controllable safety profile in clinical use.
Veterinary API — canine hyperadrenocorticism (Cushing’s disease)
Trilostane is the standard of care for both pituitary-dependent (PDH) and adrenal-dependent (ADH) hyperadrenocorticism in dogs. In a prospective study of dogs with PDH (J Vet Intern Med, 2006, doi:10.1111/j.1939-1676.2006.tb02897.x, n=23), once-daily trilostane at a median starting dose of 6.1 mg/kg achieved post-ACTH cortisol within the target range (40–150 nmol/L) in 78% of dogs at the 90-day assessment.
Endocrinology research
Trilostane is used in cell-based and rodent models as a selective 3β-HSD inhibitor, enabling researchers to study adrenal steroidogenesis independently of upstream ACTH signaling. Its high water solubility at physiological pH makes it suitable for in vitro work without organic cosolvent.
> Sourcing & Supply
Suzhou Pharmaceutical Technology Co., Ltd. is an R&D-driven pharmaceutical company with in-house synthesis and analytical capability. Small batches (up to 10 kg) are produced directly by our technical team in Suzhou. For larger commercial quantities, production is scaled up at qualified manufacturing facilities, with full export documentation provided.
- Small-batch orders (≤10 kg): synthesised by our technical team in Suzhou. Lead time 7–14 business days from order confirmation.
- Commercial bulk (>10 kg): scaled up at qualified manufacturing facilities. Lead time 14–21 business days.
We export Trilostane to buyers across South America — including Brazil, Argentina, Colombia, Chile, Peru, Ecuador, Bolivia, and Uruguay — as well as to Australia, New Zealand, Mexico, and Canada. Inquiries from European, Middle Eastern, and Asian markets are also welcome.
> Quality & Export Documentation
All Trilostane shipments are accompanied by a Certificate of Analysis (COA) confirming identity, purity, and appearance against specification. Purity is tested by HPLC against an authenticated reference standard — specification ≥98.0% on the dried substance, consistent with the British Pharmacopoeia (BP 2024) monograph for Trilostane.
| Order size | Documentation included |
| ≤10 kg (small-batch / research) | COA + MSDS |
| >10 kg (commercial bulk) | COA + MSDS + COO |
> Packaging & Logistics
- 100 g, 500 g: double-layered aluminium foil bag, heat-sealed, nitrogen-purged
- 1 kg: aluminium foil bag inside kraft paper box
- 5 kg, 10 kg: aluminium foil bag inside fibre drum
- >10 kg: negotiated on order (typically 25 kg fibre drum)
Trilostane is not classified as hazardous under IATA/IMDG — no dangerous goods surcharge applies. Shipping options: express courier (DHL/FedEx/UPS) 4–7 business days worldwide; air freight 5–10 days for 1–10 kg; sea freight 25–35 days for ≥25 kg.
> Pricing & Supply
Trilostane pricing is provided on request. We do not publish list prices as the final quote depends on order quantity, required documentation, shipping destination, and current raw material costs.
- MOQ: 100 g (research-grade, company COA)
- Sample policy: 10–50 g samples available for qualified buyers. Sample cost is credited against the first commercial order.
- Bulk discount tiers apply at 500 g, 1 kg, 5 kg, and 10 kg.
- Payment: T/T (bank transfer). 100% in advance for standard orders. Terms for larger repeat orders by arrangement.
> Frequently Asked Questions
What is the minimum order quantity for Trilostane?
The minimum order quantity for Trilostane is 100 grams. This applies to research-grade supply accompanied by our in-house COA. Orders of 1 kg or more qualify for bulk pricing with COA and MSDS included. Sample quantities of 10–50 g are available for qualified buyers prior to bulk commitment.
What documents are included with a Trilostane bulk order?
All orders include a Certificate of Analysis (COA) and MSDS issued in English. For commercial bulk orders (>10 kg), a Certificate of Origin (COO) is standard. Notarised or apostilled documents are available on request.
Can I request a Trilostane sample before placing a bulk order?
Yes. Sample quantities of 10–50 g are available for qualified buyers. Samples are dispatched within 7 business days of inquiry confirmation and are shipped via express courier. The cost of the sample is credited against your first commercial order above 1 kg. Please indicate your intended use and destination country when requesting a sample.
Do you export Trilostane to South America?
Yes. We regularly export Trilostane to buyers in Brazil, Argentina, Colombia, Chile, Peru, Ecuador, Bolivia, and Uruguay. All shipments include COA, MSDS, and COO. Lead time is typically 10–20 business days depending on destination. Please contact us for country-specific import documentation requirements.
Can buyers in Australia, New Zealand, Mexico, or Canada order Trilostane?
Yes. We supply Trilostane to buyers in Australia, New Zealand, Mexico, and Canada. Air freight to Australia and New Zealand typically takes 5–8 business days; to Mexico and Canada 5–7 business days. COA, MSDS, and COO are included with all orders.
What is Trilostane used for in veterinary medicine?
Trilostane is the standard API for treating hyperadrenocorticism (Cushing’s disease) in dogs. It inhibits 3β-hydroxysteroid dehydrogenase in the adrenal cortex, reducing overproduction of cortisol. It is the active ingredient in Vetoryl® (Dechra), the veterinary-licensed product. Dosing is typically 1–5 mg/kg once or twice daily, adjusted based on ACTH stimulation testing.
What is the mechanism of action of Trilostane?
Trilostane competitively inhibits 3β-hydroxysteroid dehydrogenase (3β-HSD), an enzyme at the junction of adrenal and gonadal steroidogenesis. By blocking this step, trilostane prevents conversion of pregnenolone to progesterone and DHEA to androstenedione, reducing downstream synthesis of cortisol, aldosterone, and androgens. The inhibition is reversible and concentration-dependent.
Is Win 24,540 the same compound as Trilostane?
Yes. Win 24,540 is the research code assigned to Trilostane by the Sterling-Winthrop pharmaceutical company during its original development in the 1970s. The two names refer to the same molecule: CAS 13647-35-3, molecular formula C₂₀H₂₇NO₃. Other documented names include Modrenal (UK brand, Wanskerne Ltd), Vetoryl (Dechra), and the INN-Latin form Trilostanum.
What is the purity of your Trilostane (CAS 13647-35-3)?
Our Trilostane (CAS 13647-35-3) is supplied at ≥98% purity as determined by HPLC, consistent with the British Pharmacopoeia (BP 2024) specification. Each batch is tested against an authenticated reference standard before release. The COA reports: assay result, appearance, melting point, and water content. Additional parameters (residual solvents, heavy metals) are available on request.
Do you supply Trilostane to Southeast Asia and the Middle East?
Yes. Trilostane is available for buyers in Singapore, Malaysia, Thailand, Indonesia, Vietnam, Philippines, UAE, Saudi Arabia, Turkey, Israel, and other countries in these regions. We handle export documentation including COO for Southeast Asian and Gulf importers. Lead time is 7–14 business days by express courier.
What is the difference between Trilostane and Vetoryl?
Vetoryl is the brand name for a trilostane-based veterinary product manufactured by Dechra Pharmaceuticals, available as licenced capsules in regulated markets. Trilostane API from Suzhou Pharmaceutical Technology Co., Ltd. is the same active pharmaceutical ingredient — CAS 13647-35-3, ≥98% purity — supplied in bulk for veterinary compounding pharmacies, research institutions, and distributors in markets where Vetoryl is not registered or where compounded formulations are used.
How is Trilostane packaged and shipped internationally?
Trilostane is shipped in double-layered, nitrogen-purged aluminium foil bags for quantities up to 1 kg, and in foil-lined fibre drums for larger orders. The compound is not classified as hazardous under IATA or IMDG regulations, so no dangerous goods surcharge applies. Typical shipping time is 4–7 business days by express courier to most global destinations.
> Related Products
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- Deslorelin | CAS 57773-65-6 — GnRH agonist used in veterinary reproductive medicine
- Selegiline HCl | CAS 14611-51-9 — MAO-B inhibitor; veterinary use for Cushing’s and cognitive dysfunction
- Metyrapone | CAS 54-36-4 — 11β-hydroxylase inhibitor; used in Cushing’s syndrome diagnosis
> Request a Quote or Sample
To request a quote or sample for Trilostane (CAS 13647-35-3), please contact us directly at Info@fmyykj.com.
Include in your inquiry: required quantity (grams or kg), destination country, documentation requirements (COA + MSDS standard; COO for bulk), intended use (veterinary compounding / research / other). We respond to all inquiries within 1 business day.
Last reviewed: June 2026