Unifiram / Noopept 272786-64-8 — China API Manufacturer | Research Grade R&D to Production

China Manufacturing Landscape for Unifiram

Unifiram (CAS 272786-64-8), a piperazine-derived ampakine compound, belongs to a class of nootropic research compounds that modulate AMPA receptor activity and have demonstrated cognitive enhancement properties in preclinical studies. While distinct from Noopept (GVS-111, CAS 157115-85-0), both compounds are frequently sourced by the same customer base of research institutions, nootropic supplement manufacturers, and pharmaceutical R&D organizations. Our quality-certified manufacturing facility in China produces high-purity Unifiram alongside other nootropic research compounds, serving the global demand from a direct manufacturer source with full quality documentation and analytical traceability.

China’s position as the primary global manufacturing source for novel research compounds and early-stage pharmaceutical intermediates is well established. Our facility combines advanced organic synthesis capabilities with the flexibility to produce relatively small-volume, high-complexity compounds at quality levels suitable for both research use and early clinical development. The domestic availability of diverse chemical building blocks and synthetic reagents, combined with experienced medicinal chemistry talent, enables rapid process development and cost-effective production of compounds like Unifiram.

Manufacturing Process & Facility

Unifiram synthesis involves a multi-step organic chemistry route centered on construction of the 2-(2-oxopyrrolidin-1-yl)acetamide core structure with the appropriate N-benzoyl piperazine substitution. Key synthetic steps include N-alkylation of pyrrolidinone with chloroacetyl chloride, amide bond formation with the functionalized piperazine moiety, and benzoylation to install the aromatic pharmacophore. Each step is optimized for yield, purity, and reproducibility through systematic process development including Design of Experiments (DoE) methodology.

The manufacturing facility includes multipurpose glass-lined and stainless steel reactors (50 L to 1,000 L) configured for flexible campaign-based production of multiple compounds, supported by preparative HPLC and column chromatography systems for polishing purification, and controlled crystallization equipment for final product isolation. The facility operates under NMPA pharmaceutical conditions with dedicated analytical laboratories equipped with HPLC-DAD, LC-MS/MS, GC-MS, and NMR spectrometry capabilities for complete compound characterization.

Quality Standards & Multi-Pharmacopeial Compliance

As a research-stage compound without established pharmacopeial monographs, Unifiram is manufactured against internal quality specifications developed in consultation with our customer base and aligned with ICH Q11 and general pharmacopeial chapter requirements for new chemical entities. HPLC purity consistently exceeds 99.0%, with individual impurities controlled below 0.3%. Full structural confirmation is performed for every batch by ¹H-NMR, ¹³C-NMR, mass spectrometry (HRMS), and IR spectroscopy.

Quality testing includes HPLC assay and related substances, residual solvent analysis by headspace GC per ICH Q3C, elemental impurities by ICP-MS, water content by Karl Fischer, melting point determination, and microbial limits testing. Certificate of Analysis includes complete spectroscopic characterization data (NMR, MS, IR) to support customer identity verification. Stability studies under ICH-aligned conditions have been conducted to establish recommended storage conditions and retest intervals.

Regulatory Documentation

Documentation packages for Unifiram are tailored to the research and development context of this compound’s current regulatory status. Standard documentation includes detailed Certificate of Analysis with full analytical and spectroscopic data, manufacturing process summary, Material Safety Data Sheet (MSDS/SDS), certificate of origin, and quality compliance certificate for the manufacturing facility. For customers pursuing IND-enabling studies or early clinical development, we provide enhanced documentation packages including detailed process descriptions, impurity characterization reports with synthesized reference standards, and preliminary stability data in CTD-compatible format.

Packaging & Logistics

Unifiram is packaged in pharmaceutical-grade amber glass bottles or HDPE containers with tamper-evident seals, available in quantities from 10 g through 10 kg per unit. All containers are sealed under nitrogen atmosphere with desiccant to protect against moisture and oxidative degradation. International shipments are dispatched via express air freight services, with typical delivery within 5-8 business days to destinations worldwide. Standard shipping documentation includes commercial invoice, packing list, CoA, MSDS, and customs classification guidance. For countries requiring specific import permits for research compounds, our logistics team provides proactive documentation support to facilitate smooth customs clearance.

Competitive Pricing & Supply Reliability

Direct competitive pricing for Unifiram is structured to support the research community with accessible pricing across a wide range of order quantities, from gram-scale evaluation samples through multi-kilogram research program supply. Quantity-based discounts are applied progressively, with significant savings available for orders exceeding 1 kg. Production lead times are typically 2-4 weeks for standard orders, with the ability to accommodate custom synthesis requests for structural analogues or isotope-labeled versions within 4-8 weeks. Our catalog of nootropic and cognitive research compounds continues to expand based on customer demand signals, and custom synthesis services are available for novel structures upon request.

Unifiram Specifications