Suzhou Pharmaceutical Technology Co., Ltd. (China) supplies Vancomycin HCl 1404-93-9 CAS 1404-93-9 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Vancomycin Hydrochloride |
|---|---|
| Structural Formula |  |
| CAS Number | 1404-93-9 |
| Alias / Common Name | Vancomycin HCl; Vancocin; Lyphocin; Vancomycin hydrochloride; Vancomycinum hydrochloridum |
| Molecular Formula | C66H76Cl3N9O24 |
| Molecular Weight | 1485.7 g/mol |
| InChIKey | LCTORFDMHNKUSG-XTTLPDOESA-N |
| Purity / Grade | 900-1050 ug/mg potency (USP, HPLC, dried basis); confirm by batch COA |
| Appearance | White to off-white lyophilised powder |
| Pharmacopoeial Standard | USP / EP |
| Storage | Room temperature (15-25 deg C), protect from moisture; refrigerated for long-term storage |
| MOQ | 100 g (evaluation); 1 kg (commercial) |
Vancomycin Hydrochloride (CAS 1404-93-9) is supplied by Suzhou Pharmaceutical Technology Co., Ltd. for B2B pharmaceutical procurement programs requiring glycopeptide antibiotic APIs with documented analytical quality. A tricyclic glycopeptide produced by Amycolatopsis orientalis fermentation, vancomycin inhibits bacterial cell wall synthesis by binding to the D-Ala-D-Ala terminus of peptidoglycan precursors. It is listed on the WHO Model List of Essential Medicines and classified as a critically important antimicrobial (CIA, highest priority) by WHO. Supply documentation includes COA, MSDS and certificate of origin for export to South America, Europe, Australia, New Zealand, Mexico and Canada.
> Applications
MRSA, Gram-Positive Bacteremia and Endocarditis
Vancomycin HCl is the reference treatment for serious gram-positive infections including MRSA bacteremia, infective endocarditis and Clostridioides difficile colitis. The IDSA MRSA guidelines (Liu C et al., Clin Infect Dis. 2011;52(3):285-292, doi:10.1093/cid/ciq146) recommend vancomycin as primary therapy for MRSA bacteremia, endocarditis, meningitis and septic arthritis. Procurement teams evaluate Vancomycin HCl API for injectable antimicrobial programs, surgical prophylaxis formulations and hospital formulary procurement across South America, Europe and global markets.
Specialty API for Injectable Antimicrobial Formulations
Vancomycin HCl is evaluated as a reference API for parenteral products requiring USP or EP pharmacopoeial compliance. Key analytical quality attributes reviewed during qualification include HPLC potency (USP 900-1050 ug/mg on dried basis), related substances (CDP-1 and degradation products, USP limits), pH of solution (2.5-4.5), water content (Karl Fischer), endotoxin for injectable-grade batches, and residual solvents (ICH Q3C). Stability studies follow ICH Q1A guidelines; typical shelf life 24-36 months at controlled room temperature.
B2B Sourcing and Supply Chain Development
Vancomycin HCl procurement programs are typically structured in three stages: analytical evaluation using reference standard comparison; qualification lot (100 g-1 kg) with extended characterisation including method transfer; and commercial supply commitment. Suzhou Pharmaceutical Technology Co., Ltd. supports all three stages with consistent documentation packages and analytical method transfer support where required.
> Sourcing & Supply
Suzhou Pharmaceutical Technology Co., Ltd. supplies Vancomycin HCl to B2B buyers in South America, Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada. Primary export destinations in South America include Argentina, Colombia, Chile, Peru, Ecuador, Uruguay, Bolivia, Brazil, Paraguay and Venezuela.
- Evaluation quantities (100 g-1 kg): shipped with COA, MSDS, analytical method summary and batch documentation.
- Commercial lots (5 kg+): supply confirmed against buyer specification, packaging format (HDPE drums or glass, nitrogen atmosphere), logistics plan and import documentation requirements.
- Lead time: stock quantities available for rapid evaluation; made-to-order batches require advance planning. Contact for current stock status and pricing.
> Quality & Documentation
Standard documentation with each Vancomycin HCl shipment: Certificate of Analysis (HPLC potency 900-1050 ug/mg, related substances including CDP-1, identification by IR and HPLC, pH, water content, residual solvents, appearance); MSDS/SDS (GHS format); Certificate of Origin. For regulated-market qualification programs, additional documents including batch production records, analytical method validation summaries and stability data can be discussed on a project basis. COA and MSDS provided in English; Spanish-language documentation available for South American import programs.
> Packaging
Vancomycin HCl API is packaged as powder in pharmaceutical-grade HDPE drums or amber glass bottles sealed under nitrogen or inert gas. Standard export pack sizes: 500 g, 1 kg, 5 kg, 10 kg per unit. Outer packaging: corrugated carton with desiccant and moisture indicator. Room-temperature air freight for small quantities; sea freight with appropriate conditioning for commercial lots. Custom packaging formats reviewed for commercial programs. Labels in English and Spanish for South American destinations.
> Pricing & MOQ
MOQ: 100 g for analytical evaluation and qualification. Commercial lots from 1 kg. Pricing is quoted by specification (USP/EP grade), analytical scope, packaging format, quantity and destination. Payment: 100% T/T before dispatch unless otherwise agreed. Spot availability and pricing quotations provided within 2 business days of inquiry with clear specification details.
> Regulatory & Compounding Context
Vancomycin HCl supplied by Suzhou Pharmaceutical Technology Co., Ltd. is intended for B2B pharmaceutical development, qualification and commercial procurement. Finished-product registration, market authorisation, labelling and distribution are the responsibility of the buying organisation. Buyers importing into South American markets (ANMAT, INVIMA, DIGEMID, ISP) should confirm API import requirements and dossier documentation needs with local regulatory counsel before placing commercial orders.
> Alias Index
- Primary name: Vancomycin Hydrochloride
- CAS Number: 1404-93-9
- Molecular formula: C66H76Cl3N9O24 (MW 1485.7 g/mol)
- InChIKey: LCTORFDMHNKUSG-XTTLPDOESA-N
- Trade names / aliases: Vancocin; Lyphocin; Vancomycin HCl; Vancomycinum hydrochloridum (Latin); Vancomycine chlorhydrate (French)
- Pharmacopoeial monograph: USP Vancomycin Hydrochloride; EP Vancomycini hydrochloridum
- Search terms: Vancomycin HCl supplier South America; Vancomycin API bulk; CAS 1404-93-9 buy; Vancomycin manufacturer China
> FAQ
What is the CAS number and molecular formula for Vancomycin HCl?
Vancomycin Hydrochloride CAS number is 1404-93-9. Molecular formula: C66H76Cl3N9O24; molecular weight: 1485.7 g/mol; InChIKey: LCTORFDMHNKUSG-XTTLPDOESA-N. The free base (Vancomycin) CAS is 1404-90-6. Pharmacopoeial synonyms: USP Vancomycin Hydrochloride, EP Vancomycini hydrochloridum.
What pharmacopoeial standard does your Vancomycin HCl meet?
Vancomycin HCl supplied by Suzhou Pharmaceutical Technology Co., Ltd. is tested to USP and EP specifications. USP key parameter: potency 900-1050 ug/mg on dried basis (HPLC). EP parameters include identification (IR), related substances (CDP-1, total impurities) and optical rotation. Full COA provided with each batch.
What documents are included with each Vancomycin HCl shipment?
Standard documents: COA (HPLC potency 900-1050 ug/mg, related substances including CDP-1, identification by IR and HPLC, pH, water content, residual solvents, appearance); MSDS/SDS (GHS); Certificate of Origin. Stability data and analytical method summaries available for formal qualification programs.
What is the minimum order quantity (MOQ) for Vancomycin HCl API?
MOQ is 100 g for initial analytical evaluation and qualification. Commercial lots from 1 kg. Smaller research quantities may be reviewed for established buyers. API qualification programs typically require evaluation, analytical transfer and qualification lot stages before commercial volumes are confirmed.
How is Vancomycin HCl packaged and shipped?
Vancomycin HCl is supplied as powder in HDPE drums or amber glass bottles sealed under nitrogen. Standard pack sizes: 500 g, 1 kg, 5 kg, 10 kg. Room-temperature air freight for small and medium quantities; sea freight with appropriate conditioning for commercial lots. All shipments include commercial invoice, packing list, COO and waybill.
Can Suzhou Pharmaceutical Technology supply Vancomycin HCl to Argentina, Colombia and Chile?
Yes. Vancomycin HCl supply to Argentina (ANMAT), Colombia (INVIMA) and Chile (ISP) is supported. Documentation packages including COA, MSDS and COO aligned to South American import requirements are provided. API import regulatory requirements for each destination should be confirmed with local regulatory counsel.
What is the difference between Vancomycin free base (CAS 1404-90-6) and Vancomycin HCl (CAS 1404-93-9)?
Vancomycin free base (CAS 1404-90-6) and Vancomycin Hydrochloride (CAS 1404-93-9) are different salt forms. The hydrochloride salt is the commercially supplied and pharmacopoeially recognised form, with MW 1485.7 g/mol vs. 1449.3 g/mol for free base. USP and EP monographs are written for the hydrochloride form, which is the standard for injectable pharmaceutical preparations.
What is the mechanism of action of Vancomycin?
Vancomycin inhibits bacterial cell wall synthesis by binding with high affinity to the D-Ala-D-Ala terminus of peptidoglycan precursors (lipid II), preventing transglycosylation and transpeptidation. This mechanism confers activity against MRSA and most beta-lactam-resistant gram-positive organisms. Resistance in VRE (vancomycin-resistant Enterococci) arises from D-Ala-D-Lac substitution, reducing binding affinity approximately 1000-fold.
What South American markets does Suzhou Pharmaceutical Technology supply Vancomycin HCl to?
Suzhou Pharmaceutical Technology Co., Ltd. supplies Vancomycin HCl to Argentina (ANMAT), Colombia (INVIMA), Chile (ISP), Peru (DIGEMID), Ecuador, Uruguay, Bolivia, Brazil (ANVISA), Paraguay and Venezuela. Documentation packages including COA, MSDS and COO aligned to each market’s import requirements are provided. Buyers in South America should confirm current API import registration requirements with local regulatory counsel.
Is Vancocin the same as Vancomycin HCl?
Vancocin is a brand name for Vancomycin Hydrochloride (CAS 1404-93-9). Other brand names and aliases include Lyphocin, Vancoled and Vancomycin HCl. The INN (International Nonproprietary Name) is Vancomycin. All refer to the same active pharmaceutical ingredient: the hydrochloride salt of the glycopeptide antibiotic produced by Amycolatopsis orientalis fermentation. Suzhou Pharmaceutical Technology supplies the API (bulk substance) rather than finished-dose Vancocin product.
Last reviewed: June 2026. Molecular data sourced from PubChem CID for CAS 1404-93-9. Clinical reference: Liu C et al., Clin Infect Dis. 2011;52(3):285-292.