Product Overview & China Production Capacity
Calcium Hydrogen Phosphate Dihydrate (Dibasic Calcium Phosphate Dihydrate / DCPD, CAS 7789-77-7, molecular formula CaHPO₄·2H₂O, MW 172.09) is a cornerstone pharmaceutical excipient used as a filler-binder in tablet manufacturing via both direct compression and wet granulation processes. Its favorable compaction characteristics, chemical inertness, and compatibility with most active pharmaceutical ingredients make it the preferred diluent for solid dosage forms. It also serves as a mineral supplement providing bioavailable calcium and phosphorus.
China dominates global DCPD production with capacity exceeding 500,000 MT annually across food, feed, and pharmaceutical grades. Our facility in Yunnan Province, strategically located near high-purity phosphate rock deposits, produces 40,000 MT/year of pharmaceutical-grade DCPD using a reaction crystallization process optimized for controlled particle morphology.
Manufacturing Standards & Quality Assurance
Manufacturing is conducted under quality certification with ISO 9001:2015 quality systems. The product meets all specifications in USP/NF, EP, BP, and ChP monographs for Calcium Hydrogen Phosphate Dihydrate. We also hold Halal and Kosher certifications for markets requiring religious compliance documentation.
In-process controls monitor crystal habit, particle size distribution (laser diffraction), and real-time moisture content. Finished product testing includes XRD phase identification, ICP-OES elemental analysis, fluoride (ISE), acid-insoluble substances, and full pharmacopeial microbiological testing. We offer multiple particle size grades including fine powder, milled, and unmilled granular to suit different tableting processes.
Technical Specifications
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder |
| Assay (CaHPO₄·2H₂O) | 98.0–105.0% |
| Calcium (Ca) | 22.0–24.5% |
| Loss on Ignition | 24.5–26.5% |
| Fluoride | ≤75 ppm |
| Chloride | ≤0.25% |
| Arsenic (As) | ≤3 ppm |
| Lead (Pb) | ≤5 ppm |
| Heavy Metals | ≤30 ppm |
| Particle Size (D50) | 20–50 µm (standard grade) |
Packaging & Export Logistics
Available in 25 kg paper-poly bags, 500 kg and 1,000 kg FIBCs with PE inner liners. Store in a dry location at 15–25°C. Shelf life is 48 months from manufacture. Non-hazardous for transport. Palletized loads are shrink-wrapped for container stuffing efficiency — 20 MT per 20′ FCL container.
We ship from Kunming (rail to port), Shanghai, and Shenzhen with comprehensive logistics support. All regulatory documentation including COA, DMF reference letters, MSDS, and certificates of origin are provided with each shipment.
China Supply Advantage
China’s proximity to world-class phosphate rock deposits and low-cost production infrastructure delivers pharmaceutical-grade DCPD at 40–55% below Western pricing. Our vertically integrated operation — from ore processing to finished excipient — eliminates intermediary margins and ensures both quality control and cost optimization throughout the value chain.
MOQ is 1,000 kg with production lead times of 7–10 business days. Annual supply contracts with price protection are available. We offer custom particle size engineering (D50 range 5–150 µm) for specific formulation requirements including direct compression, roller compaction, and wet granulation applications. Reach out for a tailored supply proposal.