Suzhou Pharmaceutical Technology Co., Ltd. (China) supplies Sucrose CAS 57-50-1 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview: Sucrose — CAS 57-50-1
Suzhou Pharmaceutical Technology supplies sucrose, CAS 57-50-1, pharmaceutical grade (≥99.5%), from qualified Chinese manufacturers. Available as granulated (D50 ~400–600 µm), fine granulated (D50 ~200–400 µm), and powdered (D50 ≤100 µm) grades. Complies with USP, EP (Ph. Eur.), BP, and NF. Each lot includes COA, MSDS, specific optical rotation confirmation, and heavy-metal certificate. Minimum 50 kg; bulk supply to Argentina, Colombia, Chile, Peru, Ecuador, and across South America by sea freight from Shanghai or Tianjin.
> Technical Profile & Specifications
Sucrose is a non-reducing disaccharide consisting of α-D-glucopyranose and β-D-fructofuranose joined by an α,β-1,2-glycosidic bond. Its non-reducing character (no free anomeric carbon) confers excellent stability in solution and compatibility with amine-containing APIs compared to reducing sugars (lactose, glucose).
| Property | Value |
|---|---|
| Product Name | Sucrose |
| Structural Formula |  |
| CAS Number | 57-50-1 |
| Molecular Formula | C₁₂H₂₂O₁₁ |
| Molecular Weight | 342.30 g/mol |
| Purity (pharma grade) | ≥99.5% |
| Appearance | White crystalline powder or granules |
| Specific Optical Rotation | +66.3° to +67.0° (c=26, water, 20 °C) |
| Solubility in Water | 200 g/100 mL (20 °C); 487 g/100 mL (100 °C) |
| Loss on Drying | ≤0.10% |
| Sulfur Dioxide | ≤15 ppm |
| Heavy Metals (as Pb) | ≤0.5 ppm |
| Conductivity | ≤35 µS/cm (10% w/v solution) |
| Melting Point | 185–187 °C (with decomposition) |
| Storage | Cool, dry; ≤25 °C, RH ≤65%; away from strong acids |
| InChIKey | CZMRCDWAGMRECN-UGDNZRGBSA-N |
> Regulatory Status: USP, EP, BP, NF
- USP (United States Pharmacopeia): Sucrose monograph; assay ≥99.5%, optical rotation, loss on drying, heavy metals, sulfate ash, microbial limits.
- EP (European Pharmacopoeia): Sucrose (Ph. Eur.); additional tests for reducing sugars, inulin, conductivity.
- BP (British Pharmacopoeia): Aligned with EP post-Brexit; Simple Syrup BP (66.7% w/w) specified.
- NF (National Formulary): Used as sweetening agent, vehicle, and tablet/capsule diluent.
- Codex Alimentarius: GSFA standard for sucrose in food products worldwide.
- South America: Accepted as excipient in formulations registered with ANMAT (Argentina), INVIMA (Colombia), ISP (Chile), DIGEMID (Peru), and ARCSA (Ecuador).
> Pharmaceutical Applications
- Oral liquid formulations: Primary sweetener and viscosity builder in syrups (85% w/v = Simple Syrup USP), elixirs, suspensions, and solutions. Sucrose at ≥65% w/v acts as a natural preservative through osmotic inhibition of microbial growth.
- Tablet direct compression & granulation: Compressible sucrose grades (spray-dried, fine granulated) serve as filler-binder in direct compression formulations. Granulation with sucrose syrup produces strong granules with excellent flow.
- Sugar-coated tablets: Traditional pan-coating process applies sucrose syrup (60–70% w/v) in multiple layers to tablet cores, producing smooth, brilliant tablets. Still widely used in Latin American markets for taste-masking and light protection.
- Lozenges & pastilles: Base material for medicated lozenges (e.g., antiseptic, antifungal) and hard candy formulations at 70–85% sucrose.
- Lyophilized biologics: Cryoprotectant and lyoprotectant for monoclonal antibodies, vaccines, and proteins. Sucrose at 5–10% w/v stabilizes protein structure during freeze-drying by replacing water in the hydrogen-bond network.
Telang C & Suryanarayanan R (J Pharm Sci. 2007;96(11):2994–3001, doi:10.1002/jps.20983, n=24 samples) showed that sucrose crystallization behavior during spray-drying is critical to long-term stability of amorphous pharmaceutical dispersions, with partially crystalline sucrose yielding inferior moisture protection versus fully amorphous sucrose.
> Food & Nutraceutical Applications
- Oral rehydration salts (ORS): WHO-recommended ORS formula contains 13.5 g/L glucose (not sucrose directly, but sucrose is used as precursor or alternative in some formulations).
- Nutraceutical capsules/tablets: Sucrose as binder or sweetener in vitamin supplements and herbal extracts for South American health product markets.
- Food encapsulation: Microencapsulation matrix for flavours, vitamins, and probiotics using spray-dried sucrose glass matrix.
> Quality Assurance & Documentation
- Assay: Polarimetric method (specific optical rotation +66.3° to +67.0°); confirms sucrose content ≥99.5%
- Reducing sugars: Fehling test or HPLC; ≤0.02% (EP method)
- Heavy metals: ICP-MS for Pb, As, Hg, Cd per USP ‹232›/‹233›
- Loss on drying: ≤0.10% (105 °C, 3 h)
- Sulfur dioxide: ≤15 ppm (Monier-Williams method)
- Microbial limits: TAMC ≤10³ CFU/g, TYMC ≤10² CFU/g, E. coli absent (USP ‹61›/‹62›)
- Conductivity: ≤35 µS/cm (10% w/v solution, 20 °C)
Documentation included with each shipment: COA, MSDS/SDS (GHS format), optical rotation report, and country-of-origin certificate. For ≤50 kg qualification orders, digital PDFs within 24 h of shipment; for >50 kg commercial orders, physical originals plus digital copies.
> Sourcing & Manufacturing Origin
China is a major global producer of pharmaceutical-grade sucrose, primarily from sugarcane (Guangxi province) and sugar beet (Inner Mongolia). Suzhou Pharmaceutical Technology sources from manufacturers operating refined sucrose purification lines with HPLC quality control and ISO 9001 certification. Our qualified manufacturers supply to Chinese domestic pharmaceutical companies and export to SE Asia, Latin America, and the Middle East.
> Packaging, Storage & Shipping
- ≤50 kg: 25-kg multi-layer kraft paper bags with PE inner liner (heat-sealed)
- 50–500 kg: Same bags on wooden pallets, stretch-wrapped
- >500 kg: 500–1000 kg jumbo big-bags for bulk orders
Storage: Keep in original packaging at ≤25 °C, RH ≤65%. Sucrose is hygroscopic at high humidity; keep away from strong acids (causes inversion) and amines. Shelf life: 5 years in sealed packaging.
Shipping: Sea freight FCL/LCL from Shanghai or Tianjin to Buenos Aires, Callao (Lima), Valparaíso, Cartagena, and Guayaquil. HS code: 1701.99.90 (refined sucrose). Air freight for qualification samples ≤5 kg. Typical transit: 28–35 days to Buenos Aires; 22–28 days to Callao or Guayaquil.
> Pricing & MOQ
- Pharmaceutical grade ≥99.5%: 50 kg qualification from USD 1.5–2.0/kg; 500–2000 kg commercial from USD 1.2–1.8/kg; >5 t from USD 0.9–1.3/kg
- Low-endotoxin grade: USD 3.0–5.0/kg (add endotoxin certificate)
- Powdered sucrose D50 ≤100 µm: +10–15% premium over granulated
MOQ: 50 kg for qualification; 500 kg for repeat commercial orders. Price validity 30 days from quotation. All prices FOB Shanghai; CIF or DDP to South American ports on request.
> Frequently Asked Questions
What purity grades of sucrose do you supply?
Three grades: Pharmaceutical ≥99.5% (USP/EP/BP/NF), Food grade ≥99.5% (Codex Alimentarius), and Industrial ≥99.0%. Pharma grade meets USP ‹611› microbial limits, heavy-metal specs (Pb ≤0.5 ppm, As ≤0.5 ppm), and SO₂ ≤15 ppm. All grades available as granulated (D50 ~400–600 µm), fine granulated (D50 ~200–400 µm), and powdered (D50 ≤100 µm). COA provided with each lot.
What documents are included with each sucrose shipment?
Standard documentation: COA with assay, loss on drying, heavy metals, SO₂, specific optical rotation, conductivity, and microbial limits; MSDS/SDS; and country-of-origin certificate. Factory attestation letters and DMF-support documents available on request. All documents in English; Spanish translations available for ANMAT, INVIMA, and ISP submissions.
Is your sucrose USP-grade suitable for pharmaceutical syrups?
Yes. Our sucrose (CAS 57-50-1) meets USP Sucrose monograph for oral liquid preparations. Simple Syrup USP is 85% w/v sucrose (850 g/L), used as vehicle, sweetener, and viscosity builder. Granulated pharma grade dissolves readily in purified water without inversion. Specific optical rotation +66.3° to +67.0° (c=26, water, 20 °C) confirmed per lot.
What is the CAS number (57-50-1) for pharmaceutical sucrose?
CAS 57-50-1. Sucrose is a non-reducing disaccharide of glucose and fructose linked by an α,β-1,2-glycosidic bond. It is not an E-number food additive (it is the base ingredient in sugar). PubChem CID 5988. Our pharma-grade sucrose ships with CAS 57-50-1 confirmed on the COA and meets USP, EP, BP, and NF specifications.
Can you supply low-endotoxin sucrose for lyophilized injectable biologics?
Yes — a low-endotoxin grade (≤0.5 EU/g) is available for use as cryoprotectant/lyoprotectant in freeze-dried injectable biologics (monoclonal antibodies, vaccines, proteins). Sucrose crystallization behavior in spray-dried formulations is critical to product stability (Telang C & Suryanarayanan R, J Pharm Sci. 2007;96(11):2994–3001, doi:10.1002/jps.20983, n=24 samples). LAL endotoxin and bioburden certificates available on request.
What is the difference between pharmaceutical and food-grade sucrose?
Pharmaceutical grade (≥99.5% USP/EP) applies stricter controls: Pb ≤0.5 ppm, As ≤0.5 ppm, Hg ≤0.1 ppm, SO₂ ≤15 ppm, loss on drying ≤0.1%, and full pharmacopoeial microbial testing. Food grade meets Codex Alimentarius or national food authority specs but may have higher heavy-metal tolerances. For any registered pharmaceutical product in South America, pharma grade is required.
What sucrose concentration is used in Simple Syrup BP?
Simple Syrup BP is 66.7% w/w sucrose (equivalent to 85% w/v). At this concentration, high osmotic pressure inhibits microbial growth. Syrup BP serves as vehicle, sweetener, and viscosity modifier in oral liquid formulations. Our pharma-grade granulated sucrose dissolves completely at room temperature; no inversion occurs under standard compounding conditions.
How is sucrose used in tablet coating?
Sugar coating (pan coating) uses sucrose syrup (60–70% w/v) applied in multiple layers: sealing, sub-coating, grossing, smoothing, and polishing. Each layer adds 15–30 µm. Sucrose coating is traditional, produces brilliant glossy tablets, and remains popular for effervescent tablets, lozenges, and taste-masked pediatric formulations across Latin America.
What packaging is available for bulk sucrose shipments to South America?
Standard: 25-kg multi-layer paper bags (PE inner liner, heat-sealed) up to 500 kg; 500–1000 kg jumbo bags for bulk orders. Sea freight FCL/LCL to Buenos Aires, Callao (Lima), Valparaíso, Cartagena, and Guayaquil. Lead time 3–4 weeks from factory. DDP and CIF Incoterms available.
What is the minimum order quantity for pharmaceutical sucrose?
MOQ is 50 kg for first qualification orders (pharma grade); 500 kg for commercial repeat orders. Pricing (FOB Shanghai): pharma grade ≥99.5% from USD 1.2–1.8/kg at 500–2000 kg. Price validity 30 days from quotation. Contact our team for project-specific CIF pricing to your South American port.
How does sucrose compare to sorbitol and mannitol as a pharmaceutical excipient?
Sucrose (sweetness 1.0×) is sweeter than sorbitol (0.6×) and mannitol (0.5×), making it superior for taste-masking in syrups and pediatric liquids. Mannitol is preferred for direct-compression tablets (non-hygroscopic) and parenteral use. Sorbitol for low-calorie formulations. Sucrose offers unmatched sweetness, high solubility (200 g/100 mL at 20 °C), and cost-effectiveness for traditional syrups and sugar-coated tablets.
Do you supply pharmaceutical sucrose to Argentina and Colombia?
Yes — Argentina and Colombia are primary markets. We ship to Buenos Aires (Exolgan terminal) and Bogotá/Medellín (via Cartagena). Documentation compatible with ANMAT and INVIMA: COA, MSDS, factory attestation letter, and phytosanitary certificate where required. DDP and CIF available. Transit 28–35 days from Shanghai or Tianjin.
> Related Pharmaceutical Excipients & Sweeteners
- Sucralose (CAS 56038-13-2) — 600× sweeter, non-caloric, suitable for diabetic formulations
- Xylitol (CAS 87-99-0) — sugar-free sweetener, caries prevention, polyol
- Succinic Acid (CAS 110-15-6) — pH modifier, buffer component in oral formulations
- Titanium Dioxide (CAS 13463-67-7) — opacifier in sugar-coated tablets and capsules
> Request a Quote — Sucrose CAS 57-50-1
Suzhou Pharmaceutical Technology supplies pharmaceutical-grade sucrose (CAS 57-50-1, ≥99.5%) in quantities from 50 kg to multi-tonne lots, with full regulatory documentation. We serve importers, formulators, and manufacturers in Argentina, Colombia, Chile, Peru, Ecuador, Bolivia, Uruguay, and worldwide. Last reviewed: 2026-06-03
Sample and research orders (≤10 kg) are dispatched with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package on request.