Suzhou Pharmaceutical Technology Co., Ltd. (China) supplies Pimobendan Veterinary API CAS 74150-27-9 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Pimobendan — Overview
Pimobendan (CAS: 74150-27-9, also known as Vetmedin and UD-CG-115BS) is a benzimidazole-pyridazinone inodilator used as a pharmaceutical API in veterinary cardiology. It is the active ingredient in Vetmedin® (Boehringer Ingelheim), the globally licensed product for canine congestive heart failure (CHF). Its dual mechanism — calcium sensitisation of cardiac myofilaments plus phosphodiesterase-3 (PDE-3) inhibition — produces positive inotropy and peripheral vasodilation simultaneously, without the arrhythmogenic risk seen with classical cardiac glycosides. Suzhou Pharmaceutical Technology Co., Ltd. supplies ≥98.5% Pimobendan API in bulk from Suzhou, China, with export to South America, Australia, and worldwide markets. Export documentation: COA and MSDS standard for all orders.
| Product Name | Pimobendan |
| Structural Formula |  |
| Alias | Vetmedin (brand); Cardisure (brand); pimobendane; UD-CG-115BS; Pimobendanum |
| CAS Number | 74150-27-9 |
| Molecular Formula | C₁₉H₁₈N₄O₂ |
| Molecular Weight | 334.4 g/mol |
| Purity | ≥98.5% (HPLC) |
| Appearance | White to yellowish-white crystalline powder |
| Storage | Below 25°C, protected from light and moisture |
> Applications
Pimobendan works through two complementary pharmacological mechanisms at the level of the cardiac myocyte. First, it sensitises the troponin C complex to intracellular calcium, increasing the force of contraction without raising intracellular Ca²⁺ — a key advantage over digoxin-type compounds that elevate calcium load and risk arrhythmia. Second, pimobendan inhibits PDE-3 in vascular smooth muscle and platelets, raising cAMP levels and producing systemic and pulmonary vasodilation. The net result is improved cardiac output alongside reduced preload and afterload.
Canine congestive heart failure — mitral valve disease and DCM
Pimobendan is the standard of care for both clinical and — following the EPIC trial — preclinical stages of canine myxomatous mitral valve disease (MMVD). In the landmark EPIC randomised controlled trial (J Vet Intern Med, 2016, doi:10.1111/jvim.14586, n=360 dogs with preclinical MMVD and cardiomegaly), pimobendan at 0.4–0.6 mg/kg/day extended the median preclinical period by 15 months compared to placebo (median 1,228 vs 766 days, p<0.0001). The EPIC trial established pimobendan as the first drug proven to delay onset of CHF in preclinical MMVD, fundamentally changing the cardiology standard of care.
Dilated cardiomyopathy (DCM)
Pimobendan is also indicated for systolic dysfunction in canine dilated cardiomyopathy (DCM), improving quality of life and prolonging survival. Occult DCM (preclinical) in Dobermann Pinschers is a growing area of veterinary clinical interest. Pimobendan API is used by veterinary compounding pharmacies to prepare custom-dosed formulations for giant breeds and cases where licensed tablet sizes are suboptimal.
> Sourcing & Supply
Suzhou Pharmaceutical Technology Co., Ltd. is an R&D-driven pharmaceutical company with in-house synthesis and analytical capability for Pimobendan API. Small batches (up to 10 kg) are produced directly by our technical team in Suzhou. For larger commercial quantities, production is scaled up at qualified manufacturing facilities, with full export documentation provided.
- Small-batch orders (≤10 kg): synthesised by our technical team in Suzhou. Lead time 10–14 business days from order confirmation.
- Commercial bulk (>10 kg): scaled up at qualified manufacturing facilities. Lead time 14–21 business days.
We export Pimobendan API to buyers across South America — including Brazil, Argentina, Colombia, Chile, Peru, Ecuador, Bolivia, and Uruguay — as well as to Australia, New Zealand, Mexico, and Canada. Inquiries from European, Middle Eastern, and Asian markets are also welcome.
> Quality & Export Documentation
All Pimobendan shipments are accompanied by a Certificate of Analysis (COA) confirming identity, purity (≥98.5% HPLC), appearance, and polymorphic form (Form A). The analytical method uses reverse-phase HPLC with a C18 column, tested against an authenticated reference standard. Our specification meets USP and EP requirements for Pimobendan.
| Order size | Documentation included |
| ≤10 kg (small-batch / research) | COA + MSDS |
| >10 kg (commercial bulk) | COA + MSDS + COO |
> Packaging & Logistics
- 100 g, 500 g: double-layered aluminium foil bag, heat-sealed, nitrogen-purged
- 1 kg: aluminium foil bag inside kraft paper box
- 5 kg, 10 kg: aluminium foil bag inside fibre drum
- >10 kg: negotiated on order (typically 25 kg fibre drum)
Pimobendan is not classified as a hazardous substance under IATA/IMDG transport regulations — no dangerous goods surcharge applies. Shipping options: express courier (DHL/FedEx/UPS) 4–7 business days worldwide; air freight 5–10 days for 1–10 kg; sea freight 25–35 days for ≥25 kg.
> Pricing & Supply
Pimobendan pricing is provided on request. We do not publish list prices as the final quote depends on order quantity, required documentation, shipping destination, and current raw material costs.
- MOQ: 100 g (research-grade, company COA)
- Sample policy: 10–50 g samples available for qualified buyers. Sample cost is credited against the first commercial order.
- Bulk discount tiers apply at 500 g, 1 kg, 5 kg, and 10 kg.
- Payment: T/T (bank transfer). 100% in advance for standard orders. Terms for larger repeat orders by arrangement.
> Frequently Asked Questions
What is the minimum order quantity for Pimobendan API?
The minimum order quantity for Pimobendan API is 100 grams. This applies to research-grade supply accompanied by our in-house COA. Orders of 1 kg or more qualify for bulk pricing with COA and MSDS included. Sample quantities of 10–50 g are available for qualified buyers prior to bulk commitment.
What documents are included with a Pimobendan bulk order?
All orders include a Certificate of Analysis (COA) and MSDS issued in English. For commercial bulk orders (>10 kg), a Certificate of Origin (COO) is standard. The COA confirms identity, purity (≥98.5% HPLC), appearance, and polymorphic form (Form A).
Can I request a Pimobendan sample before placing a bulk order?
Yes. Sample quantities of 10–50 g are available for qualified buyers. Samples are dispatched within 7 business days of inquiry confirmation and are shipped via express courier. The sample cost is credited against your first commercial order above 1 kg. Please indicate your intended use and destination country when requesting a sample.
Do you export Pimobendan API (CAS 74150-27-9) to South America?
Yes. We regularly export Pimobendan API to buyers in Brazil, Argentina, Colombia, Chile, Peru, Ecuador, Bolivia, and Uruguay. All shipments include COA, MSDS, and COO. Lead time is typically 10–20 business days depending on destination. Contact us for country-specific import documentation requirements.
Can buyers in Australia, New Zealand, Mexico, or Canada order Pimobendan?
Yes. We supply Pimobendan API to buyers in Australia, New Zealand, Mexico, and Canada. Air freight to Australia and New Zealand typically takes 5–8 business days; to Mexico and Canada 5–7 business days. COA, MSDS, and COO are included with all commercial orders.
What is Pimobendan used for in veterinary medicine?
Pimobendan is the standard API for treating congestive heart failure (CHF) in dogs caused by myxomatous mitral valve disease (MMVD) or dilated cardiomyopathy (DCM). Following the EPIC trial results, it is now also used in preclinical MMVD with cardiomegaly to delay onset of CHF. It is the active ingredient in Vetmedin® (Boehringer Ingelheim).
What is the mechanism of action of Pimobendan?
Pimobendan works by two distinct mechanisms. First, calcium sensitisation: it enhances troponin C binding affinity for Ca²⁺, boosting contractility without raising intracellular calcium load — a key safety advantage over cardiac glycosides. Second, PDE-3 inhibition: it raises cAMP in vascular smooth muscle, producing simultaneous systemic and pulmonary vasodilation and reducing preload and afterload.
Is Vetmedin an alias for Pimobendan — are they the same API?
Vetmedin is the brand name for a pimobendan-based veterinary product manufactured by Boehringer Ingelheim, available as licensed chewable tablets in regulated markets. Pimobendan API from Suzhou Pharmaceutical Technology Co., Ltd. is the same active pharmaceutical ingredient — CAS 74150-27-9, ≥98.5% purity — supplied in bulk for veterinary compounding pharmacies, research institutions, and distributors in markets where Vetmedin is not registered.
What is the purity and polymorphic form of your Pimobendan (CAS 74150-27-9)?
Our Pimobendan API is supplied at ≥98.5% purity as determined by HPLC. The polymorphic form is confirmed as Form A by XRPD testing, which is the pharmacopoeially accepted form. Each batch is released against a full COA including assay, appearance, related substances, and loss on drying.
Do you supply Pimobendan to Southeast Asia and the Middle East?
Yes. Pimobendan API is available for buyers in Singapore, Malaysia, Thailand, Indonesia, Vietnam, Philippines, UAE, Saudi Arabia, Turkey, Israel, and other countries in these regions. We handle export documentation including COO for importers in these markets. Lead time is 7–14 business days by express courier.
What is the EPIC trial and why does it matter for Pimobendan sourcing?
The EPIC trial proved pimobendan delays CHF onset by ~15 months in preclinical MMVD dogs (JVIM 2016, doi:10.1111/jvim.14586, n=360). Pimobendan at 0.4–0.6 mg/kg/day extended the median preclinical period from 766 to 1,228 days vs placebo. This result expanded the licensed indication to preclinical disease, significantly increasing global demand for pimobendan API in compounding and generic formulations.
How is Pimobendan packaged and shipped internationally?
Pimobendan API is shipped in double-layered, nitrogen-purged aluminium foil bags for quantities up to 1 kg, and in foil-lined fibre drums for larger orders. The compound is not classified as hazardous under IATA or IMDG regulations, so no dangerous goods surcharge applies. Typical shipping time is 4–7 business days by express courier to most global destinations.
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> Request a Quote or Sample
To request a quote or sample for Pimobendan API (CAS 74150-27-9), please contact us directly at Info@fmyykj.com.
Include in your inquiry: required quantity (grams or kg), destination country, documentation requirements (COA + MSDS standard; COO for bulk), intended use (veterinary compounding / research / other). We respond to all inquiries within 1 business day.
Last reviewed: June 2026